5-MeO-DMT is the most powerful psychedelic known to man. Typically, the user feels disconnected from his/her body for about 30 minutes and the notion of time and space is distorted. The experience is often described as a profound moment of bliss and awareness.

Although they're two of the most powerful psychedelics on Earth, they're not the same. DMT has a long-lasting effect, loaded with visions and physical reactions, while 5-MeO-DMT has a short-lasting effect, with intense emotions that are often "inexplicable".

5-MeO-DMT is considered a New Psychoactive Substance by the UNODC. It is illegal in countries like the US, UK, NZ, AU, and some EU countries. Also, in California and New Mexico, Incilius alvarius is listed as an endangered species, and its possession or trade is penalized.

Research conducted by Johns Hopkins University shows improvements in self-reported depression and anxiety after one session. Other studies have also provided evidence for anti-inflammatory, neuroregenerative, and anti-addiction effects of 5-MeO-DMT.