Don't trip alone!

5-MeO-DMT is by far the strongest Entheogen known to man. It is important to know that consuming this compound by yourself can be extremely dangerous. Firstly, it is known that during the experience people can stop breathing without noticing it. And secondly, if vomiting takes place, you must be rolled over on your left side, to prevent choking while laying on your back. It is, therefore, fundamental to have someone watching over you.

Don't trip alone!

5-MeO-DMT is by far the strongest Entheogen known to man. It is important to know that consuming this compound by yourself can be extremely dangerous. Firstly, it is known that during the experience people can stop breathing without noticing it. And secondly, if vomiting takes place, you must be rolled over on your left side, to prevent choking while laying on your back. It is, therefore, fundamental to have someone watching over you.

Sustainability of the Bufo Medicine

The title of this article is partly inaccurate and subjective, but it expresses best a concern that we share with many others who are riding the 5-MeO-DMT wave. It’s partly inaccurate because, as we mentioned before, the right name of the toad species that produces natural 5-MeO-DMT is Incilius alvarius, also known as the Colorado River or Sonoran Desert toad. And it’s subjective because using the word medicine to refer to this powerful psychedelic reveals the beliefs and type of approach of a certain group, but it’s not an irrefutable truth. However, it’s becoming incredibly common to find ceremonies, retreats, and activities promoting Bufo alvarius medicine, and this is how it’s primarily known in neo-shamanic and new age circles.

A Bit of History

Back in 1983, the psychonaut known as Albert Most (a.k.a. Ken Nelson) published a pamphlet sharing the first and most comprehensive information available at the time about the Sonoran Desert toad, including instructions of how to find it, extract the substance and ingest it. From then on, and due to the relative ease and freedom with which this naturally occurring 5-MeO-DMT can be found and ingested (there’s not tradition around it), it slowly started to become famous in the world of psychedelics; both in science as in alternative lifestyle circles.


Until now, Incilius alvarius is the only animal known to be able to produce 5-MeO-DMT in such quantities. By the time when those discoveries were made, the compound had only been isolated from specific plants of the Amazon basin, which have been traditionally used by native tribes in a preparation known as yopo and some types of rapé.

The Psychedelic Toad of the Sonoran Desert

The Psychedelic Toad of the Sonoran Desert

Pamphlet of Psychonaut Albert Most

Conservation and Sustainability

The IUCN’s last report of the Incilius alvarius conservation status dates from 2004[1], and it catalogs it as “least concern”. However, naturalists, scientists, and local communities have manifested a great concern in the last years, as the constant abuse, misuse and illegal trafficking of this unique species are affecting its population.


The Colorado River toad is a very special creature. It spends nine months hibernating underground during the dry season, and it comes back up during the rainy season to feed and mate for only three months. It’s the largest living toad species of the USA and a fundamental piece of the delicate balance of the Sonoran Desert’s ecosystem. The 5-MeO-DMT it naturally produces is found in its parotoid glands in the form of a venom, which is its only defense mechanism against predators. This means that every time the substance is milked, the toad will be defenseless until it produces it back. And that is just one of the issues.


Many opportunists drive once a year to the Sonoran Desert in the hunt for great loads of the toad’s venom. This activity is not regulated, and most of them don’t care about the toad’s wellbeing as they care about the money, thus the toads are mistreated and even infected with human bacteria that cause terrible diseases in their population. On the other hand, toads are very sensitive to their surroundings and they have and “inner-GPS” that allows them to locate themselves in the spaces. When taken out of that space and left randomly somewhere else, many of them will likely die before they find their way back home.

Protect the Sonoran Desert Toad 

Please Trip Responsibly

On the other hand, some local associations and organizations are trying to regulate this situation, to keep providing with the medicine in sustainable ways. To listen, support them, and chose them before the cheaper “black market” options, is a choice that reveals what you truly stand for. Another possibility that satisfies many is the synthetic option, which prevents any damage to the environment and generates very similar transformative effects.


What do you choose? Remember that all members of Bufo Village share the nature and/or origins of their 5-MeO-DMT in their profiles. You have the right to make informed and conscious decisions.

1. The IUCN Red List of Threatened Species 2004: e.T54567A11152901.

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